Dysautonomia in Autism Spectrum Disorder Case Reports of a Family With Review of the Literature

doi: x.1155/2011/129795. Epub 2011 May 31.

Dysautonomia in autism spectrum disorder: case reports of a family unit with review of the literature

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• PMID: 22937241
• PMCID: PMC3420600
• DOI: x.1155/2011/129795

Free PMC article

Dysautonomia in autism spectrum disorder: case reports of a family unit with review of the literature

Derrick Lonsdale  et al. Autism Res Treat. 2011 .

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Abstract

Instance histories of a female parent and her ii children are reported. The female parent was a recovered alcoholic. She and her two children, both of whom had symptoms that are typical of autistic spectrum disorder, had dysautonomia. All had intermittently aberrant erythrocyte transketolase studies indicating abnormal thiamine pyrophosphate homeostasis. Both children had unusual concentrations of urinary arsenic. All had symptomatic improvement with nutrition restriction and supplementary vitamin therapy but chop-chop relapsed later on ingestion of sugar, milk, or wheat. The stress of a heavy metal brunt, superimposed on existing genetic or epigenetic hazard factors, may be important in the etiology of autism spectrum disorder when in combination. Dysautonomia has been associated with several diseases, including autism, without a mutual etiology. Information technology is hypothesized that oxidative stress results in loss of cellular energy and causes retardation of difficult wiring of the brain in infancy, affecting limbic system command of the autonomic nervous system.

Figures

Figure 1

Transketolase requires TPP and magnesium as cofactors. Although the enzyme occurs twice in the hexose-monophosphate shunt, the laboratory test is for the one shown as the TPPE consequence. Transketolase TK, pyruvate dehydrogenase (PDH), alpha-ketoglutarate dehydrogenase (α-KGDH) Enzymes that all require thiamine (vitamin B1/TTFD) equally a cofactor in gild to function in carbohydrate metabolism. glyceraldehyde three-phosphate and fructose-6-phosphate. At that place are four known natural thiamine phosphate derivatives: thiamine monophosphate (TMP), thiamine diphosphate (TDP) or thiamine pyrophosphate (TPP), thiamine triphosphate (TTP), and the recently discovered adenosine thiamine triphosphate (AThTP). Thiamine pyrophosphate (TPP), also known as thiamine diphosphate (TDP), and cocarboxylase is a coenzyme for several enzymes that catalyze the dehydrogenation (decarboxylation and subsequent conjugation to Coenzyme A) of alpha-keto acids. Thiamine pyrophosphate effect really reflects the saturation status of transketolase with coenzyme.

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